Structural and biological changes in traumatic brain injury ( TBI ) - related neurodegeneration

Five epilepsy patients were implanted with micro-ECoG grids. Patients were asked to perform specific tasks depending on the placement of the micro-ECoG grid on the cerebral cortex. Tasks included repeating spoken words, flexing individual fingers, and reaching in two dimensions. Vocalized articulations of ten different words and silence were classified on a trial-by-trial basis with 82.4% accuracy. Three individual finger movements and rest were classified on a trial-by-trial basis with 62% accuracy. We were able to continuously decode the arm trajectory with a maximum correlation coefficient of 0.82 in the x-direction and 0.76 in the y-direction. These findings demonstrated that LFPs recorded by microECoG grids from the surface of the cerebral cortex contain sufficient information to provide rapid and intuitive control a BCI communication or motor prosthesis.